Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Shane McManus
PROVIDER: E-GEOD-15145 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Immunity 20090402 4
Pax5 is an essential regulator of B cell identity and function. Here, we used transgenesis and deletion mapping to identify a potent enhancer in intron 5 of the Pax5 locus. This enhancer in combination with the promoter region was sufficient to recapitulate the B lymphoid expression of Pax5. The enhancer was silenced by DNA methylation in embryonic stem cells, but became activated in multipotent hematopoietic progenitors. It contained functional binding sites for the transcription factors PU.1, ...[more]