Staging of biliary atresia at diagnosis by molecular profiling of the liver

ABSTRACT: BACKGROUND: Young age at portoenterostomy has been linked to improved outcome in biliary atresia, but pre-existing biological factors may influence the rate of disease progression. In this study, we aimed to determine whether molecular profiling of the liver identifies stages of disease at diagnosis. METHODS: We examined liver biopsies from 47 infants with biliary atresia enrolled in a prospective observational study. Biopsies were scored for inflammation and fibrosis, used for gene expression profiles, and tested for association with indicators of disease severity, response to surgery, and survival at 2 years. RESULTS: Fourteen of 47 livers displayed prominent features of inflammation (N=9) or fibrosis (N=5), with the remainder showing similar levels of both simultaneously. Differential p

ORGANISM(S): Homo sapiens

SUBMITTER: Jorge Bezerra 

PROVIDER: E-GEOD-15235 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress