Drug-inhibition of HDAC3 and epigenetic control of differentiation in Apicomplexa parasites

ABSTRACT: Plasmodium and Toxoplasma are parasites of major medical importance that belong to the Apicomplexa phylum of protozoa. These parasites transform into various stages during their life cycle and express a specific set of proteins at each stage. Although still little is known of how gene expression is controlled in Apicomplexa, histone modifications, particularly acetylation, are emerging as key regulators of parasite differentiation and stage conversion. Here, we investigated the anti-Apicomplexa effect of FR235222, a histone deacetylase (HDAC) inhibitor. We show that FR235222 is active against a variety of Apicomplexa genera, including Plasmodium and Toxoplasma, and is more potent than other HDACi such as TSA and the clinically relevant compound, pyrimethamine. We identify TgHDAC3 as the ta

ORGANISM(S): Toxoplasma gondii

SUBMITTER: Philippe Ortet 

PROVIDER: E-GEOD-15241 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress