Patterns of micro RNA expression characterize stages of human B-cell differentiation

ABSTRACT: Mature B-cell differentiation provides an important mechanism for the acquisition of adaptive immunity. Malignancies derived from mature B-cells constitute the majority of leukemias and lymphomas. These malignancies often maintain the characteristics of the normal B-cells that they are derived from, a feature that is frequently used in their diagnosis. The role of microRNAs in mature B-cells is largely unknown. Through concomitant microRNA and mRNA-profiling, we demonstrate a potential regulatory role for microRNAs at every stage of the mature B-cell differentiation process. Further, we have experimentally identified a direct role for the microRNA-regulation of key transcription factors in B-cell differentiation: LMO2 and PRDM1 (Blimp1). We also profiled microRNA of B-cell tumors derived f

ORGANISM(S): Homo sapiens

SUBMITTER: Dereje Jima 

PROVIDER: E-GEOD-15250 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress