Microarray analysis of therapeutic (GM4) and non therapeutic (GM) NOD DC

ABSTRACT: We have previously demonstrated that bone marrow-derived DC can prevent diabetes development and halt progression of insulitis in NOD mice, the mouse model of type 1 diabetes (T1D). The DC population that was most effective in this therapy had a mature phenotype, expressed high levels of costimulatory molecules and secreted low levels of IL-12p70. The protective DC therapy induced regulatory Th2 cells that shifted the dominant Th1 environment, present in NOD mice, to a mixed Th1/Th2 milieu. Microarray analysis of therapeutic and non-therapeutic DC populations revealed several novel molecules that could play important roles in the observed DC-mediated therapy. The therapeutic DC population expressed a unique pattern of costimulatory molecules and chemokines, which were confirmed by flow cy

ORGANISM(S): Mus musculus

SUBMITTER: Rajan Munshi 

PROVIDER: E-GEOD-15320 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress