Specificity of the zebrafish host transcriptome response to acute and chronic mycobacterial infection

ABSTRACT: Pathogenic mycobacteria have the ability to survive within macrophages and persist inside granulomas composed of host immune cells. The complex host-pathogen interactions that determine the outcome of a mycobacterial infection process result in marked alterations of the host gene expression profile. Here we used the zebrafish model to investigate the specificity of the host response to infections with two mycobacterium strains that give distinct disease outcomes: an acute disease with early lethality or a chronic disease with granuloma formation, caused by Mycobacterium marinum strains Mma 20 and E11, respectively. We performed a microarray study of different stages of disease progression in adult zebrafish and found that the acute and the chronic strains evoked partially overlapping host

ORGANISM(S): Danio rerio

SUBMITTER: Anna Magdalena Zakrzewska 

PROVIDER: E-GEOD-15328 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress