Transcription profiling of mouse skeletal muscle gene expression after myostatin knockout in mature animals

ABSTRACT: RNA from 5 mice with postdevelopmental knockout of myostatin and 5 mice with normal myostatin expression was analyzed with comprehensive oligonucleotide microarrays. Myostatin depletion affected the expression of several hundred genes at nominal P < 0.01, but fewer than a hundred effects were statistically significant according to a more stringent criterion (false discovery rate < 5%). Most of the effects were less than 1.5-fold in magnitude. In contrast to previously-reported effects of constitutive myostatin knockout, postdevelopmental knockout did not downregulate expression of genes encoding slow isoforms of contractile proteins or genes encoding proteins involved in energy metabolism. Several collagen genes were expressed at lower levels in the myostatin-deficient muscles, and this le

ORGANISM(S): Mus musculus

SUBMITTER: Stephen Welle 

PROVIDER: E-GEOD-15349 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress