DNA vaccination series 1
Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Asa Andersson
PROVIDER: E-GEOD-1538 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Impaired autoimmune T helper 17 cell responses following DNA vaccination against rat experimental autoimmune encephalomyelitis.
Andersson Asa A Isaksson Magnus M Wefer Judit J Norling Anna A Flores-Morales Amilcar A Rorsman Fredrik F Kämpe Olle O Harris Robert A RA Lobell Anna A
PloS one 20081110 11
<h4>Background</h4>We have previously shown that vaccination with DNA encoding the encephalitogenic peptide myelin oligodendrocyte glycoprotein (MOG)(91-108) (pMOG) suppresses MOG(91-108)-induced rat Experimental Autoimmune Encephalomyelitis (EAE), a model for human Multiple Sclerosis (MS). The suppressive effect of pMOG is dependent on inclusion of CpG DNA in the plasmid backbone and is associated with early induction of Interferon (IFN)-beta.<h4>Principal findings</h4>In this study we examined ...[more]
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