Gene expression profile of embryonic retinas expressing c-hairy1, Delta-1, or Wnt2b

ABSTRACT: Expression profile of embryonic retinas expressing exogenous c-hairy1, Delta-1, or Wnt2b. These genes inhibits neuronal differentiation, and the results provide insight into the mechanism that keeps retinal progenitor cells undifferentiated. In the vertebrate retina, stem cell-like progenitor cells are maintained in a distinct region, called the ciliary marginal zone (CMZ). Canonical Wnt signaling regulates the maintenance of the progenitor cells in the CMZ. However, its downstream molecular mechanisms have remained largely unclear. Here, we show that c-hairy1, an established Notch signaling effector, mediates the Wnt-dependent maintenance of CMZ progenitor cells in chickens. Interestingly, unlike other developmental contexts where Hes gene expression is regulated by Notch signaling, the

ORGANISM(S): Gallus gallus

SUBMITTER: Shinichi Nakagawa 

PROVIDER: E-GEOD-15382 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress