FOXP3-mediated inhibition of the global gene regulator SATB1 is required for maintaining regulatory T cell commitment

ABSTRACT: Regulatory T (Treg) cells are involved in self tolerance, immune homeostasis, prevention of autoimmunity, and suppression of immunity to pathogens or tumours. The forkhead transcription factor FOXP3 is essential for Treg cell development and function as mutations in FOXP3 cause severe autoimmunity in mice and humans. However, the FOXP3-dependent molecular mechanisms leading to this severe phenotype are not well understood. Here we introduce the chromatin remodelling enzyme SATB1 (special AT-rich sequence-binding protein-1) as an important target gene of FOXP3. So far, SATB1 has been associated with normal thymic T-cell development, peripheral T-cell homeostasis, TH1/TH2 polarization, and reprogramming of gene expression. In natural and induced murine and human FOXP3+ Treg cells SATB1 expre

ORGANISM(S): Homo sapiens

SUBMITTER: Marc Beyer 

PROVIDER: E-GEOD-15390 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress