Gene expression profiling differentiates autism case-controls and phenotypic variants of autism spectrum disorders

ABSTRACT: Autism spectrum disorders (ASD) are neurodevelopmental disorders characterized by delayed/abnormal language development, deficits in social interaction, repetitive behaviors and restricted interests. The heterogeneity in clinical presentation of ASD, likely due to different etiologies, complicates genetic/biological analyses of these disorders. DNA microarray analyses were conducted on 116 lymphoblastoid cell lines (LCL) from individuals with idiopathic autism who are divided into 3 phenotypic subgroups according to severity scores from the commonly used Autism Diagnostic Interview-Revised questionnaire and age-matched, nonautistic controls. Statistical analyses of gene expression data from control LCL against that of LCL from ASD probands identify genes for which expression levels are

ORGANISM(S): Homo sapiens

SUBMITTER: AnhThu Nguyen 

PROVIDER: E-GEOD-15402 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress