Expression of survivin in lung eosinophils is associated with pathology in a mouse model of allergic asthma 2

ABSTRACT: Humans vary markedly in their propensity to develop asthma, despite often being exposed to similar environmental stimuli. Similarly, mouse strains vary in susceptibility to airways pathology in experimental asthma. Sensitization and aerosol challenge with ovalbumin (OVA) induces eosinophil accumulation, mucus production and airways obstruction in BALB/c and C57BL/6 mice. In contrast, CBA/Ca mice show relatively little pathology. Allergen-induced production of IL-4, IL-5, IL-10 and IFN-g was detected in all three strains, with BALB/c mice generating the highest levels of IL-4, IL-5 and IL-10. Microarray analysis was used to identify genes differentially regulated in lung tissue after OVA challenge. Differentially regulated genes in the lungs of the asthma-susceptible C57BL/6 and BALB/c stra

ORGANISM(S): Mus musculus

SUBMITTER: Ashley Connolly 

PROVIDER: E-GEOD-15414 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress