Candidate genes for alcohol preference in alcohol-preferring and non-preferring reciprocal congenic rats

ABSTRACT: The goal of this study was to identify candidate genes that may influence alcohol consumption by comparing gene expression in 5 brain regions of alcohol-naïve iP and P.NP rats. Background: Selectively bred P (alcohol preferring) and NP (alcohol non-preferring) rats differ greatly in alcohol preference, in part due to a highly significant QTL on chromosome 4. Reciprocal congenic strains in which the iP chromosome 4 QTL interval was transferred to the iNP background (NP.P) and the iNP chromosome 4 QTL was transferred to the iP background (P.NP) exhibited alcohol consumption scores that correlated with the introgressed interval. The goal of this study was to identify candidate genes that may influence alcohol consumption by comparing gene expression in 5 brain regions of alcohol-naïve iP and

ORGANISM(S): Rattus norvegicus

SUBMITTER: Mark Kimpel 

PROVIDER: E-GEOD-15415 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress