Identification of SULF2 as a novel transcriptional target of p53 by use of integrated genomic analyses.

ABSTRACT: Microarray analysis has been useful for identifying the targets of many transcription factors. However, gene expression changes in response to transcription factor perturbation reveal both direct transcriptional targets and secondary gene regulation. By integrating RNA interference, gene expression profiling, and chromatin immunoprecipitation technologies, we identified a set of 32 direct transcriptional targets of the tumor suppressor p53. Of these 32 genes, 11 are not currently associated with the core p53 pathway. From among these novel pathway members, we focused on understanding the connection between p53 and SULF2, which encodes an extracellular heparan sulfate 6-O-endosulfatase that modulates the binding of growth factors to their cognate receptors and that has been shown to functio

ORGANISM(S): Homo sapiens

SUBMITTER: Michele Cleary 

PROVIDER: E-GEOD-15440 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress