GEMINI (Gastric Encyclopedia of Molecular Interactions and Nodes for Intervention) Phases A-C

ABSTRACT: Genome-wide mRNA expression profiles of 25 unique gastric cancer cell lines (GCCLs). Gastric cancer (GC) is the second leading cause of global cancer mortality, with individual gastric tumors displaying significant heterogeneity in their deregulation of various oncogenic pathways. We aim to identify major oncogenic pathways in GC that robustly impact patient survival and treatment response. We used an in silico strategy based on gene expression signatures and connectivity analytics to map patterns of oncogenic pathway activation in 25 unique GCCLs, and in 301 primary gastric cancers from three independent patient cohorts. Of 11 oncogenic pathways previously implicated in GC, we identified three predominant pathways (proliferation/stem cell, NF-kB, and Wnt/b-catenin) deregulated in the majo

ORGANISM(S): Homo sapiens

SUBMITTER: Chia-Huey Ooi 

PROVIDER: E-GEOD-15455 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress