Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Dr. Hyam Leffert
PROVIDER: E-GEOD-15476 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Koch Katherine S KS Maeda Shin S He Guobin G Karin Michael M Leffert Hyam L HL
Biochemical and biophysical research communications 20090124 2
Mice lacking hepatocyte IKKbeta (Ikkbeta(Delta hep)) are defective in TNFalpha-activation of hepatocellular transcription factor NF-kappaB, and highly susceptible to hepatotoxicity. Following diethylnitrosamine (DEN) exposure, Ikkbeta(Delta hep) mice develop more hepatocellular carcinoma (HCC) than control mice due partly to enhanced DEN-induced hepatocyte death. Here we show that Ikkbeta(Delta hep) hepatocytes display growth advantages over normal hepatocytes consisting of precocious PCNA and c ...[more]