Transcription profiling of rat new model of cholangiocarcinoma progression mimicking the human cancer

ABSTRACT: Validation of preclinical models of intrahepatic cholangiocarcinoma progression that reliably recapitulate altered molecular features of the human disease would provide an important resource for suggesting and testing of novel target-based therapies against this devastating cancer. In this study, comprehensive gene expression profiling in a novel orthotopic rat model of intrahepatic cholangiocarcinoma progression was carried out in an effort to identify potential therapeutic targets relevant to the progressive human cancer. Microarray analysis was performed on intrahepatic cholangiocarcinomas formed at 10, 15, and 25 days after bile duct inoculation of neu-transformed rat cholangiocytes (BDEneu cells) into rat liver and on peritoneal metastases at the 25 day time period, compared with non-

ORGANISM(S): Rattus norvegicus

SUBMITTER: Catherine Dumur 

PROVIDER: E-GEOD-15498 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress