Human liver stem cells-derived microvesicles accelerate hepatic regeneration in partially hepatectomized rats

ABSTRACT: Several studies indicate that adult stem cells may improve the recovery from acute tissue injury. It has been suggested that they may contribute to tissue regeneration by the release of paracrine factors promoting proliferation of tissue resident cells. However, the factors involved remain unknown. In the present study we found that microvesicles (MV) derived from human liver stem cells (HLSC) were able to stimulate in vitro proliferation and apoptosis resistance of human and rat hepatocytes. These effects required internalization of MV in the hepatocytes by an alpha4 integrin-dependent mechanism. However, when treated with RNase, MV despites their internalization were unable to induce hepatocyte proliferation and apoptosis resistance, suggesting an RNA dependent effect. Microarray analysi

ORGANISM(S): Homo sapiens

SUBMITTER: Ciro Tetta 

PROVIDER: E-GEOD-15569 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress