Transcriptome profiling identifies HMGA2 as a novel gene in melanoma progression

ABSTRACT: The identification of novel tumor-specific markers may improve understanding of melanoma progression and prognostic accuracy. Whole genome expression profiling of 46 primary melanomas, 12 metastases, and 16 normal skin samples using Affymetrix U133 PLUS 2.0 array generated gene lists including both known and new melanoma genes. The molecular genetic alterations contributing to the pathogenesis of melanoma are incompletely defined and few independent prognostic features have been identified beyond the pathologic characteristics of the primary tumor. Early stage melanoma is frequently curable, in contrast to the inferior prognosis of melanomas with regional lymph nodes involvement and the incurability of distant metastatic disease. The identification of novel tumor-specific markers may impro

ORGANISM(S): Homo sapiens

SUBMITTER: Leon Raskin 

PROVIDER: E-GEOD-15605 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress