Increased antigen cross-presentation but impaired cross-priming after activation of PPARγ

ABSTRACT: Increased antigen cross-presentation but impaired cross-priming after activation of PPARγ is mediated by up-regulation of B7H1 Dendritic cells (DCs) are able to take up exogenous antigens and present antigen-derived peptides on MHC class I molecules, a process termed cross-presentation. The mannose receptor (MR), an endocytic receptor expressed on a variety of antigen-presenting cells (APCs), has been demonstrated to target soluble antigens exclusively towards cross-presentation. In this study, we investigated the role of the murine nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ), a ligand-activated transcription factor with immunomodulatory properties, in MR-mediated endocytosis and cross-presentation of the model antigen ovalbumin (OVA). We could demonstrate both

ORGANISM(S): Mus musculus

SUBMITTER: Sven Burgdorf 

PROVIDER: E-GEOD-15616 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress