Transcription profiling of mouse Stat3flx/flx/NIC breast tumors compared to wild type NIC tumors

ABSTRACT: A Stat3-dependent transcription regulatory network involved in inflammation and metastasis is identified. Analyses of the gene expression data revealed that Stat3flx/flx/NIC tumors exhibited a significant reduction in the expression of factors involved in both tumor angiogenesis (fibronectin, von willebrand factor, annexin a3, thrombopoietin, fibulin 5) and in the acute phase inflammatory response (cebpd, osmr, saa1, saa2) Experiment Overall Design: Common reference design. 8 samples including RNA extracted from 3 pools of Stat3wt/wt/NIC (WT) tumor tissues (5 individual tumor samples per pool) and 5 individual Stat3flx/flx/NIC (Homo) tumor tissue samples.

ORGANISM(S): Mus musculus

SUBMITTER: Solmaz Shahalizadeh 

PROVIDER: E-GEOD-15632 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress