Methylation changes occurring in early postnatal liver development
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Robert Waterland
PROVIDER: E-GEOD-15634 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Epigenomic profiling indicates a role for DNA methylation in early postnatal liver development.
Waterland Robert A RA Kellermayer Richard R Rached Marie-Therese MT Tatevian Nina N Gomes Marcus V MV Zhang Jiexin J Zhang Li L Chakravarty Abrita A Zhu Wei W Laritsky Eleonora E Zhang Wenjuan W Wang Xiaodan X Shen Lanlan L
Human molecular genetics 20090520 16
The question of whether DNA methylation contributes to the stabilization of gene expression patterns in differentiated mammalian tissues remains controversial. Using genome-wide methylation profiling, we screened 3757 gene promoters for changes in methylation during postnatal liver development to test the hypothesis that developmental changes in methylation and expression are temporally correlated. We identified 31 genes that gained methylation and 111 that lost methylation from embryonic day 17 ...[more]
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