Microarray analysis of FoxP3-expressing or non-expressing subsets of human CD4+ T cells

ABSTRACT: Gene expression profiles of subsets of CD4+ T cells according to their expression of FoxP3 and CD45RA were compared. Abstract: FoxP3 is a key transcription factor for the development and function of natural CD4+ regulatory T cells (Tregs). Here we show that human FoxP3+CD4+ T cells are composed of three phenotypically and functionally distinct subpopulations: CD45RA+FoxP3low resting Tregs (rTregs) and CD45RA-FoxP3high activated Tregs (aTregs), both of which are suppressive in vitro, and cytokine-secreting CD45RA-FoxP3low non-suppressive T cells. The proportion of the three subpopulations characteristically altered in cord blood, aged individuals, and patients with immunological diseases. Terminally differentiated aTregs rapidly die while rTregs proliferate and convert into aTregs in vit

ORGANISM(S): Homo sapiens

SUBMITTER: Makoto Miyara 

PROVIDER: E-GEOD-15659 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress