Lenses expression profile of DBL oncogene transgenic mice

ABSTRACT: The Dbl family of proteins represents a large group of proto-oncogenes involved in cell growth regulation. Alterations of the normal function of these proteins lead to pathological processes such as developmental disorders and neoplastic transformation. We have generated transgenic mice introducing the onco-Dbl cDNA sequences linked to the metallothionein promoter into the germ line of FVB mice and found that onco-Dbl expression affected proliferation, migration and differentiation of lens epithelial cells. We used high density oligonucleotide microarray to define the transcriptional profile induced by Dbl in the lenses of transgenic mice and observed modulation of genes encoding proteins promoting epithelial-mesenchymal transition (EMT). Moreover, genes encoding proteins involved in the

ORGANISM(S): Mus musculus

SUBMITTER: Paolo Fardin 

PROVIDER: E-GEOD-15694 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress