Gene expression in macrophages stimulated with LPS in conditions allowing or inhibiting NFAT activation

ABSTRACT: Macrophages and dendritic cells (DCs) differently contribute to the generation of coordinated immune system responses against infectious agents. They interact with microbes through germline-encoded pattern-recognition receptors (PRRs), which recognize molecular patterns expressed by various microorganisms. Upon antigen binding, PRRs instruct DCs for the appropriate priming of natural killer cells, followed by specific T-cell responses. Once completed the effector phase, DCs reach the terminal differentiation stage and eventually die by apoptosis. By contrast, following antigen recognition, macrophages initiate first the inflammatory process and then switch to an anti-inflammatory phenotype for the restoration of tissue homeostasis. Following lipopolysaccharide (LPS)-stimulation the initiat

ORGANISM(S): Mus musculus

SUBMITTER: Ivan Zanoni 

PROVIDER: E-GEOD-15721 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress