Generation of induced pluripotent stem cells by efficient reprogramming of adult bone marrow cells

ABSTRACT: Reprogramming of somatic cells provides potential for the generation of specific cell types, which could be a key step in the study and treatment of human diseases. In vitro reprogramming of somatic cells into a pluripotent embryonic stem (ES) cellM-bM-^@M-^Slike state has been reported by retroviral transduction of murine fibroblasts using four embryonic transcription factors or through cell fusion of somatic and pluripotent stem cells. The generation of reprogrammed pluripotent cells using a somatic cell donor source such as bone marrow (BM) or peripheral blood is of particular therapeutic interest because of the relative ease of harvesting these cell types. Here we show that mouse adult BM mononuclear cellsM-oM-

ORGANISM(S): Mus musculus

SUBMITTER: Kenji Nagao 

PROVIDER: E-GEOD-15775 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress