Global genetic robustness of the alternative splicing machinery in C. elegans

ABSTRACT: Alternative splicing is considered a major mechanism for creating multicellular diversity from a limited repertoire of genes. Different isoforms can be produced at the same time in the same cell type and their ratios can be the same or different between divergent genotypes. Here, we studied genetic variation in alternative splicing patterns in a large recombinant inbred population of C. elegans, using whole-genome tiling arrays. This experiment allowed us to detect heritable differences in gene expression with exquisite sensitivity and resolution, and we detected 435 genes with substantial heritable variation for at least one exon. Nonetheless, we find only a very small number of examples of heritable variation in alternative splicing (22 transcripts), and most of these genes co-localize w

ORGANISM(S): Caenorhabditis elegans

SUBMITTER: Yang Li 

PROVIDER: E-GEOD-15778 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress