Interplay between c-Jun and TAp73M-NM-1/M-NM-2 contributes to the apoptosis-survival balance

ABSTRACT: The p53-family member p73 functions in various cellular signaling pathways and can have tumor suppressor properties. Several isoforms of p73 exist that differ considerably in their function. Whereas the functions of the N-terminal isoforms (TA and M-NM-^TNp73) and their opposing pro- and anti-apoptotic roles became evident, the functional differences of the distinct C-terminal spliceforms of TAp73 have remained unclear. Here, we characterized the genomic binding sites for TAp73M-NM-1 and TAp73M-NM-2 and identified a specific p73 consensus binding-motif. Furthermore, an AP1 motif is strongly enriched close to binding sites for TAp73M-NM-1. These AP1 motif-containing target genes are selectively upregulated by TAp73M-NM-1, while their mRNA expression is repressed upon TAp73M-NM-2 induction.

ORGANISM(S): Homo sapiens

SUBMITTER: Marion Lohrum 

PROVIDER: E-GEOD-15780 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress