New specific molecular targets for radiochemotherapy in colorectal cancer

ABSTRACT: A promising treatment for patients with advanced colorectal cancer is preoperative radiochemotherapy. The early side effects of this treatment have been considered to be acceptable. The aim of this study was to identify the effects of preoperative radiochemotherapy (PRT) on gene expression in tumour and normal colon rectal tissue form the same patients, before and after PRT. For that purpose, tissue samples from ten patients with operable rectal adenocarcinomas were collected for use in whole genome–microarray based gene expression analysis. A factorial experimental design allowed us to look solely at the radiation effect on tumours. This resulted in 4496 differentially expressed genes in tumour tissue with p<0.05. In addition to known markers for radiochemotherapy, a Gene Set Enrichmen

ORGANISM(S): Homo sapiens

SUBMITTER: Endre Anderssen 

PROVIDER: E-GEOD-15781 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress