Identification of differentially expressed genes between clinical and bovine-biased Escherichia coli O157:H7 genotypes

ABSTRACT: Escherichia coli O157:H7 strains have been classified into different genotypes based on the presence of specific shiga toxin-encoding bacteriophage insertion sites. Genotypes that are predominant in clinical isolates are named clinical genotypes and those that are isolated mostly from bovine sources are bovine-biased genotypes. To determine whether inherent differences in gene expression could possibly explain the variation in infectivity of these genotypes, we compared the expression patterns of O157:H7 strains isolated from cattle, which belonged to either clinical genotype 1 or bovine-biased genotype 5. Important virulence factors of O157, including locus of enterocyte effacement, enterohemolysin, and pO157 plasmid encoded genes, showed increased expression in clinical genotype. Genes

ORGANISM(S): Escherichia coli

SUBMITTER: Thomas Besser 

PROVIDER: E-GEOD-15783 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress