Lymphoid tissue specific homing of bone marrow-derived dendritic cells

ABSTRACT: Because of their potent immunoregulatory capacity, dendritic cells (DCs) have been exploited as therapeutic tools to boost immune responses against tumors or pathogens, or dampen autoimmune or allergic responses. Murine bone marrow-derived DCs (BM-DCs) are the closest known equivalent of the blood monocyte-derived DCs that have been used for human therapy. Current imaging methods have proven unable to properly address the migration of injected DCs to small and deep tissues in mice and humans. This study presents the first extensive analysis of BM-DC homing to lymph nodes (and other selected tissues) after intravenous and intraperitoneal inoculation. Following intravenous delivery, DCs accumulated in the spleen, and preferentially in the pancreatic and lung-draining lymph nodes. In contrast

ORGANISM(S): Mus musculus

SUBMITTER: Remi Creusot 

PROVIDER: E-GEOD-15784 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress