Latexin is downregulated in human upper digestive track tumors and exhibits tumor suppressor potential

ABSTRACT: Latexin (Lxn) was originally isolated as a tissue specific marker of rat neuron. It is expressed in various tissues of humans and many other vertebrates. Lxn inhibits human carboxypeptidase A4 (hCPA4), whose expression is induced by histone deacetylase inhibitors in prostate cancer cells, and is associated with cancer progression. Structural analysis has shown significant similarity between Lxn protein and the tumor suppressor protein TIG1. Recent reports have demonstrated Lxn functions in the negative control of hematopoietic stem cell numbers (HSC) in mice. In the present study, an anti-Lxn monoclonal antibody 1G11 was generated and Western blot analysis showed that Lxn was expressed mainly in the cytoplasm of numerous human cell lines. Immunohistochemical analysis in gastric cancer tiss

ORGANISM(S): Homo sapiens

SUBMITTER: Jianqing Zhao 

PROVIDER: E-GEOD-15787 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress