Expression data from NS398-treated and control HT29 colon adenocarcinoma cell line samples
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Ferenc Sipos
PROVIDER: E-GEOD-15799 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Reversal of gene expression changes in the colorectal normal-adenoma pathway by NS398 selective COX2 inhibitor.
Galamb O O Spisák S S Sipos F F Tóth K K Solymosi N N Wichmann B B Krenács T T Valcz G G Tulassay Z Z Molnár B B
British journal of cancer 20100119 4
<h4>Background and aims</h4>Treatment of colorectal adenomas with selective cyclooxygenase-2 inhibitors can contribute to the chemoprevention of colorectal cancer (CRC), but the molecular background of their effect is not fully understood. We analysed the gene expression modulatory effect of N-(2-cyclohexyloxy-4-nitrophenyl)-methanesulfonamide (NS398) on HT29 cells to be correlated with expression data gained from biopsy samples.<h4>Methods</h4>HT29 colon adenocarcinoma cells were treated with N ...[more]
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