Responses of S. aureus to stress caused by sublethal concentration of cationic antimicrobial peptides

ABSTRACT: Understanding how pathogens respond to antimicrobial peptides, and how this compares to currently available antibiotics, is crucial to optimizing antibiotic therapy. Staphylococcus aureus has several known resistance mechanisms against human cationic antimicrobial peptides (CAMPs). We aim to determine how S. aureus responds to sheep and frog CAMPs, and whether this response is associated with resistance. Gene expression changes in Staphylococcus aureus Newman cells exposed to linear CAMPs were analyzed by DNA microarray. Three antimicrobial peptides were used in the analysis, two of them are derived from frog, temporin L and dermaseptin K4-S4(1-16), one is from sheep, ovispirin-1. The peptides induced the VraSR cell-wall regulon and several other genes which are also upregulated in cells t

ORGANISM(S): Staphylococcus aureus

SUBMITTER: HUYGHE Antoine 

PROVIDER: E-GEOD-15800 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress