Transcription profiling of thyroid follicles treated with IL-1 alpha, TNF alpha, or IFN gamma Disease)

ABSTRACT: Graves’ disease is characterized by goiter, palpitation and exophthalmos (Merseburg’s trias). However, a few patients develop exophthalmos even though their thyroid function is normal, a condition known as euthyroid Graves’ disease (EGD). It remains unknown why these patients remain euthyroid, even though they have potent thyroid-stimulating antibody (TSAb). To investigate whether the immunoglobulins (IgGs) obtained from EGD patients elicit thyroid hormone-releasing activity (THRA), thyroid follicles obtained from Graves’ patients were cultured in agarose-coated culture dishes, and 125I incorporated into the thyroid follicles and organic 125I (mainly de novo-synthesized 125I-T3+125I-T4) released into the culture medium by TSH or purified IgGs were determined as thyroid hormone-releasing a

ORGANISM(S): Homo sapiens

SUBMITTER: Kanji Sato 

PROVIDER: E-GEOD-15838 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress