Host lung gene expression patterns predict the etiology of infectious pneumonias

ABSTRACT: Rationale: Lower respiratory tract infections continue to exact unacceptable worldwide mortality, often because the infecting pathogen cannot be identified. The respiratory epithelia provide protection from pneumonias through organism-specific generation of antimicrobial products, offering potential insight into the identity of infecting pathogens. Objective: This study assesses the capacity of the host gene expression response to infection to predict lower respiratory pathogens without reliance on culture data. Methods: Mice were inhalationally challenged with S. pneumoniae, P. aeruginosa, A. fumigatus or PBS prior to whole genome gene expression microarray analysis of their pulmonary parenchyma. Characteristic gene expression patterns for each condition were identified, allowing the

ORGANISM(S): Mus musculus

SUBMITTER: Scott Evans 

PROVIDER: E-GEOD-15869 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress