Microarray data from control and pericyte-deficient mouse brain microvascular transcriptomes

ABSTRACT: The blood-brain barrier (BBB) consists of specific physical barriers, enzymes and transporters, which together maintain the necessary extracellular environment of the central nervous system (CNS). The main physical barrier is found in the CNS endothelial cell, and depends on continuous complexes of tight junctions combined with reduced vesicular transport. Other possible constituents of the BBB include extracellular matrix, astrocytes and pericytes, but the relative contribution of these different components to the BBB remains largely unknown. Here we demonstrate a direct role of pericytes at the BBB in vivo. Using a set of adult viable pericyte-deficient mouse mutants we show that pericyte deficiency increases the permeability of the BBB to water and a range of low-molecular-mass and high

ORGANISM(S): Mus musculus

SUBMITTER: Bengt Johansson 

PROVIDER: E-GEOD-15892 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress