Interleukin-7 promotes monocyte/macrophage arrest on endothelial cells

ABSTRACT: Background: It is recognized that atherosclerosis can regresses at least in animal models. However, little is known about the mechanisms. We induced regression of advanced atherosclerosis in apolipoprotein E deficient (APOE­/­) mice and studied underlying mechanisms. Unexpectedly, our study led to the role of interleukin-7 (IL-7) in atherogenesis. Methods and Results: We treated APOE­/­ mice fed a high cholesterol diet for 30 weeks to induce advanced lesions with a helper-dependent adenoviral vector expressing human apoE3 (HDAd-gE3), and analyzed the regression of atherosclerosis after 41 weeks. Using microarray analysis, we identified IL-7 as one of most significantly affected genes by lowering cholesterol. To answer why IL-7 is downregulated by reduced cholesterol, we studied effects of

ORGANISM(S): Mus musculus

SUBMITTER: Kazuhiro Oka 

PROVIDER: E-GEOD-15914 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress