Transcription profiling of mouse pneumonectomy vs. sham treated time course to identify mesenchymal signature of post-pneumonectomy lung regeneration in adult mice

ABSTRACT: The adult human lung has a very limited capacity to regenerate functional alveoli. In contrast, adult mice have a remarkable capacity for neoalveolarization following either lung resection or injury. The molecular basis for this unique capability to regenerate lung tissue in mice is largely unknown. We examined the transcriptomic responses to single lung pneumonectomy in adult mice in order to elucidate prospective molecular signaling used in this species during lung regeneration. Unilateral left pneumonectomy or sham thoracotomy was performed under general anesthesia (n = 8 mice per group for each of the four time points). Total RNA was isolated from the remaining lung tissue at four time points post-surgery (6 hours, 1 day, 3 days, 7 days) and analyzed using microarray technology. The ob

ORGANISM(S): Mus musculus

SUBMITTER: Julia Paxson 

PROVIDER: E-GEOD-15999 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress