Microarray analysis of colonic mucosa gene expression in wild type and foxo4 knock out mice

ABSTRACT: Analysis of mechano-regulation of tenocyte metabolism at gene expression level. The hypothesis tested in the present study was that cyclic tensile strain influence the balance of anabolism/catabolism of tenocytes. Forkhead box O (FoxO) proteins are a family of transcription factors implicated in many biological processes including immune regulation. In this study, we found that mice null for Foxo4, a member of the FoxO family, are more susceptible to 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis than wild type controls. To understand the mechanism of elevated colitis susceptibility and the nature of the TNBS-induced colitis in Foxo4-null mice, we performed microarray analysis with mucosal cDNA samples from large intestines of untreated, ethanol and TNBS-treated wild type and

ORGANISM(S): Mus musculus

SUBMITTER: Zhi-Ping Liu 

PROVIDER: E-GEOD-16033 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress