Transcription profiling of mouse mammary gland gene expression and tumor growth following chronic social isolation

ABSTRACT: Clinical studies have revealed that social support improves the outcome of cancer patients while epidemiological studies suggest that social isolation increases the risk of death associated with several chronic diseases. However, the precise biological consequences of an unfavorable social environment have not been defined. To do so, robust, reproducible pre-clinical models are needed to study the mechanisms whereby an adverse environment impacts on gene expression and cancer biology. Because random assignment of inbred laboratory mice to well-defined social environments allows accurate and repeated measurements of behavioral and endocrine parameters, transgenic mice provide a pre-clinical framework with which to begin to determine gene-environment mechanisms. In this study, we found tha

ORGANISM(S): Mus musculus

SUBMITTER: Suzanne Conzen 

PROVIDER: E-GEOD-16110 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress