Integrative approach for prioritizing cancer genes in sporadic colon cancer

ABSTRACT: The current multistep carcinogenesis models of colon cancer do not fully capture the genetic heterogeneity of the disease, which is additionally complicated by the presence of passenger and driver genetic alterations. The aim of the present study was to select in the context of this significant heterogeneity additional genes functionally related to colon cancer development. Methods: High-throughput copy number and gene expression data of 36 microsatellite stable sporadic colon cancers resected from patients of a single Institution characterized for mutations in APC, KRAS, TP53 and loss of 18q were analyzed. Genes whose expression correlated with the underlying copy number pattern were selected and their association with the above listed mutations and overall survival was evaluated. Results

ORGANISM(S): Homo sapiens

SUBMITTER: Andrea Lampis 

PROVIDER: E-GEOD-16125 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress