The response of Mycobacterium tuberculosis to reactive oxygen and nitrogen species

ABSTRACT: The bacteriostatic and bactericidal effects and the corresponding expression profiles of Mycobacterium tuberculosis to representative oxidative and nitrosative stresses were investigated by growth and survival studies and whole genome expression analysis. The response of M. tuberculosis to a range of hydrogen peroxide (H2O2) concentrations tended to fall into three distinct categories: (1) low level exposure resulted in induction of few H2O2 sensitive genes, (2) intermediate exposure resulted in massive transcriptional changes without an effect on growth or survival, and (3) high exposure resulted in a muted transcriptional response and eventual death. Nitric oxide (NO) exposure initiated much of the same transcriptional response as H2O2. However, unlike H2O2 exposure, NO exposure affecte

ORGANISM(S): Mycobacterium tuberculosis

SUBMITTER: Martin Voskuil 

PROVIDER: E-GEOD-16146 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress