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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression induced by trace fear conditioning in murine hippocampus

ABSTRACT: Gene expression profiling following different learning paradigms may help in defining the moleular pathways of memory formation. In this study we analyzed the gene expression pattern of murine hippocampus at different time points (0.5 h, 2h, 6h) after trace fear conditioning. We compared trained mice with naive mice that remained in their homecages. Keywords: Time course We used 3 arrays for each experimental condition. Each array was hybridized witha a pool of RNA of 6 animals.

ORGANISM(S): Mus musculus

SUBMITTER: Daniela Toniolo

PROVIDER: E-GEOD-16158 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Temporal gene expression profile of the hippocampus following trace fear conditioning.

Sirri Alessandra A Bianchi Veronica V Pelizzola Mattia M Mayhaus Manuel M Ricciardi-Castagnoli Paola P Toniolo Daniela D D'Adamo Patrizia P

Brain research 20091024

In this paper we report the results of gene expression profiling of C57Bl/6N mice hippocampus after trace fear conditioning (TFC), and the identification of genes regulated at early and late steps after conditioning. Several of the genes regulated at early steps following TFC appeared common to many training protocols. At later stages (2 and 6 h), most of the genes identified were different from those identified following other learning paradigms resulting in memory consolidation. At 6 h after t ...[more]

PMID: 19857472

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