Regulation of Vertebrate Nervous System-Specific Alternative Splicing and Development by an SR-Related Protein

ABSTRACT: Alternative splicing is a key process underlying the evolution of increased proteomic and functional complexity and is especially prevalent in the mammalian nervous system. However, the factors and mechanisms governing nervous system-specific alternative splicing are not well understood. Through a genome-wide computational and expression profiling strategy, we have identified a tissue- and vertebrate-restricted Ser/Arg (SR)-repeat splicing factor, the neural-specific SR-related protein of 100 kDa (nSR100). We show that nSR100 regulates an extensive network of brain-specific alternative exons enriched in genes that function in neural cell differentiation. nSR100 acts by increasing the levels of the neural/brain-enriched polypyrimidine tract binding protein and by interacting with its target

ORGANISM(S): Mus musculus

SUBMITTER: Simone Superina 

PROVIDER: E-GEOD-16187 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress