Expression data from Snail over-expressing non-small cell lung cancer cell lines

ABSTRACT: Snail is a zinc-finger transcription factor best known for its ability to down-regulate E-cadherin. Its established significance in embryology and organogenesis has been expanded to include a role in the tumor progression of a number of human cancers. In addition to E-cadherin, it has more recently been associated with the down-regulation and up-regulation of a number of other genes that affect important malignant phenotypes. After establishing the presence of up-regulated Snail in human non-small cell lung cancer specimens, we used microarrays to detail the global programme of gene expression in non-small cell lung cancer cell lines stably transduced to over-express Snail as compared to vector control cell lines. Non-small cell lung cancer cell lines (H441, H292, H1437) were stably transd

ORGANISM(S): Homo sapiens

SUBMITTER: Steven Dubinett 

PROVIDER: E-GEOD-16194 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress