Transcription profiling of human peripheral blood from relapsing-remitting MS patients either untreated or treated with glatiramer acetate or interferon beta

ABSTRACT: One of our new major finding among the genes that contributes to MS susceptibility is ICSBP1. The so called disease modifying therapies like interferon-beta (IFN-β), possibly acting on the peripheral T-cells, reduce the disease activity and the clinical progression, with a MRI-detectable effect in preventing lesion burden and cerebral atrophy development in RR-MS. It suggests a critical role of peripheral blood mononuclear cells (PBMCs) immune response and modulation in developing inflammation in the brain. We tested the hypothesis that the genetic effect of the susceptible allele ICSBP1 can impact the gene expression profile of molecules belonging to the interferon pathway. We therefore interrogated the PBMC for changes in gene expression profile. We correlate those changes with the mino

ORGANISM(S): Homo sapiens

SUBMITTER: Philip De Jager 

PROVIDER: E-GEOD-16214 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress