Analysis of cardiac gene expression in response to isoproterenol-induced heart failure (part 1)

ABSTRACT: Myoglobin knockout mice (myo-/-) adapt to the loss of myoglobin by the activation of a variety of compensatory mechanisms on the structural and functional level. In order to analyze to what extent myo-/- mice would tolerate cardiac stress we used the model of chronic isoproterenol application to induce cardiac hypertrophy in myo-/- mice and wild type (WT) controls. After 14 d of isoproterenol infusion cardiac hypertrophy in WT and myo-/- mice reached a similar level. WT mice developed lung oedema and left ventricular dilatation indicating the development of heart failure. In contrast, myo-/- mice displayed conserved cardiac function and no signs of heart failure. Analysis of the cardiac gene expression profile using 40 k mouse oligonucleotide arrays showed that isoproterenol affected the e

ORGANISM(S): Mus musculus

SUBMITTER: Antje Lindecke 

PROVIDER: E-GEOD-16243 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress