Transcription profiling of human lymphatic tissue from HIV-1 infected individuals reveals stage-specific, gene-expression signatures in HIV-1 infection

ABSTRACT: Untreated HIV-1 infection progresses through acute and asymptomatic stages to AIDS. While each of the three stages has well-known clinical, virologic and immunological characteristics, much less is known of the molecular mechanisms underlying each stage. Here we report lymphatic tissue microarray analyses revealing for the first time stage-specific patterns of gene expression during HIV-1 infection. We show that while there is a common set of key genes with altered expression throughout all stages, each stage has a unique gene-expression signature. The acute stage is most notably characterized by increased expression of hundreds of genes involved in immune activation, innate immune defenses (e.g.MDA-5, TLR-7 and -8, PKR, APOBEC3B, 3F, 3G), adaptive immunity, and in the pro-apoptotic Fas-Fa

ORGANISM(S): Homo sapiens

DISEASE(S): acute HIV-1 infection

SUBMITTER: qingsheng li 

PROVIDER: E-GEOD-16363 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress