CHO cells with enhanced and abolished gamma-secretase activity

ABSTRACT: γ-secretase is an intra-membrane-cleaving aspartyl protease implicated in the processing of a wide range of type I membrane proteins including the Notch receptor and the amyloid-β precursor protein (APP). It thus regulates a diverse array of cellular and biological processes including the differentiation of neuronal embryonic stem cells, or intestinal stem cells, with the latter controlling the self-renewing of the intestinal epithelium. Indeed, proteolysis of these proteins by γ-secretase triggers signaling cascades by releasing intracellular domains (ICDs) which, following association with adaptor proteins and nuclear translocation, modulate the transcription of different genes by binding directly to their promoters. The pronounced proliferative and regenerative effects of Notch sign

ORGANISM(S): Cricetulus griseus

SUBMITTER: Matthias Cacquevel 

PROVIDER: E-GEOD-16379 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress